Computational Model Library

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EMMIT is an end-user developed agent-based simulation of malaria transmission. The simulation’s development is a case study demonstrating an approach for non-technical investigators to easily develop useful simulations of complex public health problems. We focused on malaria transmission, a major global public health problem, and insecticide resistance (IR), a major problem affecting malaria control. Insecticides are used to reduce transmission of malaria caused by the Plasmodium parasite that is spread by the Anopheles mosquito. However, the emergence and spread of IR in a mosquito population can diminish the insecticide’s effectiveness. IR results from mutations that produce behavioral changes or biochemical changes (such as detoxification enhancement, target site alterations) in the mosquito population that provide resistance to the insecticide. Evolutionary selection for the IR traits reduces the effectiveness of an insecticide favoring the resistant mosquito population. It has been suggested that biopesticides, and specifically those that are Late Life Acting (LLA), could address this problem. LLA insecticides exploit Plasmodium’s approximate 10-day extrinsic incubation period in the mosquito vector, a delay that limits malaria transmission to older infected mosquitoes. Since the proposed LLA insecticide delays mosquito death until after the exposed mosquito has a chance to produce several broods of offspring, reducing the selective pressure for resistance, it delays IR development and gives the insecticide longer effectivity. Such insecticides are designed to slow the evolution of IR thus maintaining their effectiveness for malaria control. For the IR problem, EMMIT shows that an LLA insecticide could work as intended, but its operational characteristics are critical, primarily the mean-time-to-death after exposure and the associated standard deviation. We also demonstrate the simulation’s extensibility to other malaria control measures, including larval source control and policies to mitigate the spread of IR. The simulation was developed using NetLogo as a case study of a simple but useful approach to public health research.

The Netlogo model is a conceptualization of the Moria refugee camp, capturing the household demographics of refugees in the camp, a theoretical friendship network based on values, and an abstraction of their daily activities. The model then simulates how Covid-19 could spread through the camp if one refugee is exposed to the virus, utilizing transmission probabilities and the stages of disease progression of Covid-19 from susceptible to exposed to asymptomatic / symptomatic to mild / severe to recovered from literature. The model also incorporates various interventions - PPE, lockdown, isolation of symptomatic refugees - to analyze how they could mitigate the spread of the virus through the camp.

The Episim framework builds upon the established transportation simulation MATSim and is capable of tracking agents’ movements within a network and thus computing infection chains. Several characteristics of the virus and the environment can be parametred, whilst the infection dynamics is computed based upon a compartment model. The spread of the virus can be mitigated by restricting the agents’ activity in certain places.

Peer reviewed Minding Norms in an Epidemic Does Matter

Klaus G. Troitzsch | Published Saturday, February 27, 2021 | Last modified Monday, September 13, 2021

This paper tries to shed some light on the mutual influence of citizen behaviour and the spread of a virus in an epidemic. While the spread of a virus from infectious to susceptible persons and the outbreak of an infection leading to more or less severe illness and, finally, to recovery and immunity or death has been modelled with different kinds of models in the past, the influence of certain behaviours to keep the epidemic low and to follow recommendations of others to apply these behaviours has rarely been modelled. The model introduced here uses a theory of the effect of norm invocations among persons to find out the effect of spreading norms interacts with the progress of an epidemic. Results show that norm invocations matter. The model replicates the histories of the COVID-19 epidemic in various region, including “second waves” (but only until the end of 2021 as afterwards the official statistics ceased to be reliable as many infected persons did not report their positive test results after countermeasures were relieved), and shows that the calculation of the reproduction numbers from current reported infections usually overestimates the “real” but in practice unobservable reproduction number.

This repository includes an epidemic agent-based model that simulates the spread of Covid-19 epidemic. Normal.nlogo is the main file, while Exploring-zoning.nlogo and Exploring-Testing-With-Tracking.nlogo are modefied models to test the two strategies and run experiments.

PopComp

Andre Costopoulos | Published Thursday, December 10, 2020

PopComp by Andre Costopoulos 2020
andre.costopoulos@ualberta.ca
Licence: DWYWWI (Do whatever you want with it)

I use Netlogo to build a simple environmental change and population expansion and diffusion model. Patches have a carrying capacity and can host two kinds of populations (APop and BPop). Each time step, the carrying capacity of each patch has a given probability of increasing or decreasing up to a maximum proportion.

NetLogo agent-based model to simulate the transmission of COVID-19 in a university dormitory. User can set the number of initial students, buildings, floors, rooms, number of initially infected, and transmission rate. They can also test the effect of masks, sanitizations, elevator allowance, and visits on the effect of the SEIR curve.

The model simulates the spread of a virus through a synthetic network with a degree distribution calibrated on close-range contact data. The model is used to study the macroscopic consequences of cross-individual variability in close-range contact frequencies and to assess whether this variability can be exploited for effective intervention targeting high-contact nodes.

This agent-based model was built as part of a replication effort of Jeness et al.’s work (linked below). The model simulates an MSM sexual activity network for the purpose of modeling the effects of respectively PrEP and ART on HIV prevention. The purpose of the model is to explore the differences between differerent interpretations of the NIH Indication Guidelines for PrEP.

Our model is hybrid agent-based and equation based model for human air-borne infectious diseases measles. It follows an SEIR (susceptible, exposed,infected, and recovered) type compartmental model with the agents moving be-tween the four state relating to infectiousness. However, the disease model canswitch back and forth between agent-based and equation based depending onthe number of infected agents. Our society model is specific using the datato create a realistic synthetic population for a county in Ireland. The modelincludes transportation with agents moving between their current location anddesired destination using predetermined destinations or destinations selectedusing a gravity model.

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