The TechNet_04 is an abstract model that embeds a simple cultural tranmission process in an environment where interaction is structured by spatially-situated networks.

ForagerNet3_Demography is a non-spatial ABM for exploring hunter-gatherer demography. Key methods represent birth, death, and marriage. The dependency ratio is an imporant variable in many economic decisions embedded in the methods.

ForagerNet3_Demography_V2 is a non-spatial ABM for exploring hunter-gatherer demography. This version (developed from FN3D_V1) contains code for calculating the ratio of old to young adults (the “OY ratio”) in the living and dead populations.

The purpose of this model is to examine equity and efficiency in crop production across a system of irrigated farms, as a function of maintenance costs, assessed water fees, and the capacity of farmers to trade water rights among themselves.

The purpose of the model is to explore how the unique socioeconomic variables underlying Kibera, local interactions, and the spread of a rumor, may trigger a riot.

Using Sierra Leone as a test case, the purpose of the model is to explore the role of geography in a resource-driven war. An ABM is integrated with geographic information systems (GIS) for this purpose.

The ForagerNet3_Demography model is a non-spatial ABM designed to serve as a platform for exploring several aspects of hunter-gatherer demography.

Style_Net_01 is a spatial agent-based model designed to serve as a platform for exploring geographic patterns of tool transport and discard among seasonally mobile hunter-gatherer populations. The model has four main levels: artifact, person, group, and system. Persons make, use, and discard artifacts. Persons travel in groups within the geographic space of the model. The movements of groups represent a seasonal pattern of aggregation and dispersal, with all groups coalescing at an aggregation site during one point of the yearly cycle. The scale of group mobility is controlled by a parameter. The creation, use, and discard of artifacts is controlled by several parameters that specify how many tools each person carries in a personal inventory, how many times each tool can be used before it is discarded, and the frequency of tool usage. A lithic source (representing a geographically-specific, recognizable source of stone for tools) can be placed anywhere in the geographic space of the model.

EMMIT is an end-user developed agent-based simulation of malaria transmission. The simulation’s development is a case study demonstrating an approach for non-technical investigators to easily develop useful simulations of complex public health problems. We focused on malaria transmission, a major global public health problem, and insecticide resistance (IR), a major problem affecting malaria control. Insecticides are used to reduce transmission of malaria caused by the Plasmodium parasite that is spread by the Anopheles mosquito. However, the emergence and spread of IR in a mosquito population can diminish the insecticide’s effectiveness. IR results from mutations that produce behavioral changes or biochemical changes (such as detoxification enhancement, target site alterations) in the mosquito population that provide resistance to the insecticide. Evolutionary selection for the IR traits reduces the effectiveness of an insecticide favoring the resistant mosquito population. It has been suggested that biopesticides, and specifically those that are Late Life Acting (LLA), could address this problem. LLA insecticides exploit Plasmodium’s approximate 10-day extrinsic incubation period in the mosquito vector, a delay that limits malaria transmission to older infected mosquitoes. Since the proposed LLA insecticide delays mosquito death until after the exposed mosquito has a chance to produce several broods of offspring, reducing the selective pressure for resistance, it delays IR development and gives the insecticide longer effectivity. Such insecticides are designed to slow the evolution of IR thus maintaining their effectiveness for malaria control. For the IR problem, EMMIT shows that an LLA insecticide could work as intended, but its operational characteristics are critical, primarily the mean-time-to-death after exposure and the associated standard deviation. We also demonstrate the simulation’s extensibility to other malaria control measures, including larval source control and policies to mitigate the spread of IR. The simulation was developed using NetLogo as a case study of a simple but useful approach to public health research.

Identifying how organisms respond to environmental stressors remains of central importance as human impacts continue to shift the environmental conditions for countless species. Some mammals are able to mitigate these environmental stressors at the cellular level, but the mechanisms by which cells are able to do this and how these strategies vary among species is not well understood. At the cellular level, it is difficult to identify the temporal dynamics of the system through empirical data because fine-grained time course samples are both incomplete and limited by available resources. To help identify the mechanisms by which animal cells mitigate extreme environmental conditions, we propose an agent-based model to capture the dynamics of the system. In the model, agents are regulatory elements and genes, and are able to impact the behaviors of each other. Rather than imposing rules for these interactions among agents, we will begin with randomized sets of rules and calibrate the model based on empirical data of cellular responses to stress. We will apply a common-garden framework to cultured cells from 16 mammalian species, which will yield genomic data and measures of cell morphology and physiology when exposed to different levels of temperature, glucose, and oxygen. These species include humans, dolphins, bats, and camels, among others, which vary in how they respond to environmental stressors, offering a comparative approach for identifying mechanistic rules whereby cells achieve robustness to environmental stressors. For calibration of the model, we will iteratively select for rules that best lead to the emergent outcomes observed in the cellular assays. Our model is generalized for any species, any cell type, and any environmental stressor, offering many applications of the model beyond our study. This study will increase our understanding of how organisms mitigate environmental stressors at the cellular level such that we can better address how organisms are impacted by and respond to extreme environmental conditions.