Computational Model Library

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GenoScope

Kristin Crouse | Published Wednesday, May 29, 2024

Identifying how organisms respond to environmental stressors remains of central importance as human impacts continue to shift the environmental conditions for countless species. Some mammals are able to mitigate these environmental stressors at the cellular level, but the mechanisms by which cells are able to do this and how these strategies vary among species is not well understood. At the cellular level, it is difficult to identify the temporal dynamics of the system through empirical data because fine-grained time course samples are both incomplete and limited by available resources. To help identify the mechanisms by which animal cells mitigate extreme environmental conditions, we propose an agent-based model to capture the dynamics of the system. In the model, agents are regulatory elements and genes, and are able to impact the behaviors of each other. Rather than imposing rules for these interactions among agents, we will begin with randomized sets of rules and calibrate the model based on empirical data of cellular responses to stress. We will apply a common-garden framework to cultured cells from 16 mammalian species, which will yield genomic data and measures of cell morphology and physiology when exposed to different levels of temperature, glucose, and oxygen. These species include humans, dolphins, bats, and camels, among others, which vary in how they respond to environmental stressors, offering a comparative approach for identifying mechanistic rules whereby cells achieve robustness to environmental stressors. For calibration of the model, we will iteratively select for rules that best lead to the emergent outcomes observed in the cellular assays. Our model is generalized for any species, any cell type, and any environmental stressor, offering many applications of the model beyond our study. This study will increase our understanding of how organisms mitigate environmental stressors at the cellular level such that we can better address how organisms are impacted by and respond to extreme environmental conditions.

Swidden farming by individual households

C Michael Barton | Published Sunday, April 27, 2008 | Last modified Saturday, April 27, 2013

Swidden Farming is designed to explore the dynamics of agricultural land management strategies.

Residents planned behaviour of waste sorting to explore urban situations

Jonathan Edgardo Cohen | Published Wednesday, June 07, 2023 | Last modified Thursday, March 14, 2024

Municipal waste management (MWM) is essential for urban development. Efficient waste management is essential for providing a healthy and clean environment, for reducing GHGs and for increasing the amount of material recycled. Waste separation at source is perceived as an effective MWM strategy that relays on the behaviour of citizens to separate their waste in different fractions. The strategy is straightforward, and many cities have adopted the strategy or are working to implement it. However, the success of such strategy depends on adequate understanding of the drivers of the behaviour of proper waste sorting. The Theory of Planned Behaviour (TPB) has been extensively applied to explain the behaviour of waste sorting and contributes to determining the importance of different psychological constructs. Although, evidence shows its validity in different contexts, without exploring how urban policies and the built environment affect the TPB, its application to urban challenges remains unlocked. To date, limited research has focused in exposing how different urban situations such as: distance to waste bins, conditions of recycling facilities or information campaigns affect the planned behaviour of waste separation. To fill this gap, an agent-based model (ABM) of residents capable of planning the behaviour of waste separation is developed. The study is a proof of concept that shows how the TPB can be combined with simulations to provide useful insights to evaluate different urban planning situations. In this paper we depart from a survey to capture TPB constructs, then Structural Equation Modelling (SEM) is used to validate the TPB hypothesis and extract the drivers of the behaviour of waste sorting. Finally, the development of the ABM is detailed and the drivers of the TPB are used to determine how the residents behave. A low-density and a high-density urban scenario are used to extract policy insights. In conclusion, the integration between the TPB into ABMs can help to bridge the knowledge gap between can provide a useful insight to analysing and evaluating waste management scenarios in urban areas. By better understanding individual waste sorting behaviour, we can develop more effective policies and interventions to promote sustainable waste management practices.

The ABM model is designed to model the adaptability of farmers in DTIM. This model includes two groups of farmers and local government admins agents. Farmers with different levels, with low WP of DTIM, are looking for economic benefits and reduced irrigation and production costs. Meanwhile, the government is looking for strategic goals to maintain water resources’ sustainability. The local government admins employ incentives (subsidies in this study) to encourage farmers to DTIM. In addition, it is used as a tool for supervision and training farmers’ performance. Farmers are currently harvesting water resources with irrigation systems and different levels of technology, and they intend to provide short-term benefits. Farmers adjust the existing approach based on their knowledge of the importance of DTIM and propensity to increase WP and cost-benefit evaluation. DTIM has an initial implementation fee. Every farmer can increase WP by using government subsidies. If none of the farmers create optimal use of water resources, access to water resources will be threatened in the long term. This is considered a hypothetical cost for farmers who do not participate in DTIM. With DTIM, considering that local government admins’ facilities cover an essential part of implementation costs, farmers may think of profiting from local government admins’ facilities by selling that equipment, especially if the farmers in the following conditions may consider selling their developed irrigation equipment. In this case, the technology of their irrigation system will return to the state before development.
- When the threshold of farmers’ propensity to DTIM is low (for example, in the conditions of scarcity of access to sufficient training about the new irrigation system or its role in reducing the cost and sustainability of water resources)
- When the share of government subsidy is high, and as a result, the profit from the sale of equipment is attractive, especially in conditions of inflation.
- Finally, farmers’ honesty threshold should be reduced based on the positive experience of profit-seeking and deception among neighbors.
Increasing the share of government subsidies can encourage farmers to earn profits. Therefore, the government can help increase farmers’ profits by considering the assessment teams at different levels with DTIM training . local government admins evaluations monitor the behavior of farmers. If farmers sell their improved irrigation system for profit, they may be deprived of some local government admins’ services and the possibility of receiving subsidies again. Assessments The local government admins can increase farmers’ honesty. Next, the ABM model evaluates local government admins policies to achieve a suitable framework for water resources management in the Miandoab region.

This ABM simulates problem solving agents as they work on a set of tasks. Each agent has a trait vector describing their skills. Two agents might form a collaboration if their traits are similar enough. Tasks are defined by a component vector. Agents work on tasks by decreasing tasks’ component vectors towards zero.

The simulation generates agents with given intrapersonal functional diversity (IFD), and dominant function diversity (DFD), and a set of random tasks and evaluates how agents’ traits influence their level of communication and the performance of a team of agents.

Modeling results highlight the importance of the distributions of agents’ properties forming a team, and suggests that for a thorough description of management teams, not only diversity measures based on individual agents, but an aggregate measure is also required.

Leptospirosis is a neglected, bacterial zoonosis with worldwide distribution, primarily a disease of poverty. More than 200 pathogenic serovars of Leptospira bacteria exist, and a variety of species may act as reservoirs for these serovars. Human infection is the result of direct or indirect contact with Leptospira bacteria in the urine of infected animal hosts, primarily livestock, dogs, and rodents. There is increasing evidence that dogs and dog-adapted serovar Canicola play an important role in the burden of leptospirosis in humans in marginalized urban communities. What is needed is a more thorough understanding of the transmission dynamics of Leptospira in these marginalized urban communities, specifically the relative importance of dogs and rodents in the transmission of Leptospira to humans. This understanding will be vital for identifying meaningful intervention strategies.
One of the main objectives of MHMSLeptoDy is to elucidate transmission dynamics of host-adapted Leptospira strains in multi-host system. The model can also be used to evaluate alternate interventions aimed at reducing human infection risk in small-scale communities like urban slums.

We use an agent-based 3D model to reveal the behavioral dynamics of real-world cases. The target of the simulation is the Peshawar massacre. The previous 2-D model has three main problems which can be solved by our 3-D model. Under the key action rules, our model matches the real target case exactly. Based on the optimal solution, we precisely match the results of the real cases, such as the number of deaths and injuries. We also explore the importance of adding height (constructed as a 3D model) to the model.

Studies of colonization processes in past human societies often use a standard population model in which population is represented as a single quantity. Real populations in these processes, however, are structured with internal classes or stages, and classes are sometimes created based on social differentiation. In this present work, information about the colonization of old Providence Island was used to create an agent-based model of the colonization process in a heterogeneous environment for a population with social differentiation. Agents were socially divided into two classes and modeled with dissimilar spatial clustering preferences. The model and simulations assessed the importance of gregarious behavior for colonization processes conducted in heterogeneous environments by socially-differentiated populations. Results suggest that in these conditions, the colonization process starts with an agent cluster in the largest and most suitable area. The spatial distribution of agents maintained a tendency toward randomness as simulation time increased, even when gregariousness values increased. The most conspicuous effects in agent clustering were produced by the initial conditions and behavioral adaptations that increased the agent capacity to access more resources and the likelihood of gregariousness. The approach presented here could be used to analyze past human colonization events or support long-term conceptual design of future human colonization processes with small social formations into unfamiliar and uninhabited environments.

RaMDry - Rangeland Model in Drylands

Pascal Fust Eva Schlecht | Published Friday, January 05, 2018 | Last modified Friday, April 01, 2022

RaMDry allows to study the dynamic use of forage ressources by herbivores in semi-arid savanna with an emphasis on effects of change of climate and management. Seasonal dynamics affects the amount and the nutritional values of the available forage.

This model builds on the Armature distribution within the PaleoscapeABM model, which is itself a variant of the PaleoscapeABM available here written by Wren and Janssen, and.

This model aims to explore where and how much shellfish is discarded at coastal and non-coastal locations by daily coastal foraging. We use this model’s output to test the idea that we can confidently use the archaeological record to evaluate the importance of shellfish in prehistoric people’s diets.

The recognition that aquatic adaptations likely had significant impacts on human evolution triggered an explosion of research on that topic. Recognizing coastal foraging in the past relies on the archaeological signature of that behavior. We use this model to explore why some coastal sites are very intensely occupied and see if it is due to the shellfish productivity of the coast.

Displaying 10 of 27 results importance clear search

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